Article
CYP3A5 polymorphisms and their effects on tacrolimus exposure in an ethnically diverse South African renal transplant population.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde - 29 Jan 2020
Muller W K, Dandara C, Manning K, Mhandire D, Ensor J, Barday Z, Freercks R
Abstract excerpt
BACKGROUND: Tacrolimus forms the cornerstone for immunosuppression in solid-organ transplantation. It has a narrow therapeutic window with wide inter- and intra-patient variability (IPV). Cytochrome P-450 3A5 (CYP3A5) is the main enzyme involved in tacrolimus metabolism, and rs776746A>G is the most frequently studied polymorphism in the CYP3A5 gene. The rs776746A>G (i.e. CYP3A5*3) single-nucleotide...
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