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Article

Relationship of CYP3A5 genotype and ABCB1 diplotype to tacrolimus disposition in Brazilian kidney transplant patients.

British journal of clinical pharmacology - 1 Aug 2014

Cusinato Diego Alberto C, Lacchini Riccardo, Romao Elen A, Moysés-Neto Miguel, Coelho Eduardo B

Abstract excerpt

AIMS: Tacrolimus (TAC) is one of the most successful immunosuppressive drugs in transplantation. Its pharmacokinetics (PK) and pharmacogenetics (PG) have been extensively studied, with many studies showing the influence of CYP3A5 on TAC metabolism and bioavailability. However, data concerning the functional significance of ABCB1 polymorphisms are uncertain due to inconsistent results. We evaluated the association...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to Brazil

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcineurin Inhibitors

Share to Cytochrome P-450 CYP3A

Share to Graft Rejection

Share to Kidney Transplantation

Share to Tacrolimus

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Source

Open in PubMed Open full text

Identifiers

PMID: 24528196
DOI: 10.1111/bcp.12345
PMCID: PMC4137828

Genes

ABCB1
GCG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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