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Article

An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation.

Proceedings of the National Academy of Sciences of the United States of America - 9 Nov 2010

Nadeau Mathieu, Georges Romain O, Laforest Brigitte, Yamak Abir, Lefebvre Chantal, Beauregard Janie, Paradis Pierre, Bruneau Benoit G, Andelfinger Gregor, Nemer Mona

Abstract excerpt

In humans, septal defects are among the most prevalent congenital heart diseases, but their cellular and molecular origins are not fully understood. We report that transcription factor Tbx5 is present in a subpopulation of endocardial cells and that its deletion therein results in fully penetrant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GATA4 Transcription Factor

Share to Haploinsufficiency

Share to Heart Defects, Congenital

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Share to Nitric Oxide Synthase Type III

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Source

Open in PubMed Open full text

Identifiers

PMID: 20974940
DOI: 10.1073/pnas.0914888107
PMCID: PMC2984205

Genes

TBX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20974940-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation.PMID 20974940Read ↗

Cooperative interaction between GATA5 and NF-ATc regulates endothelial-endocardial differentiation of cardiogenic cellsSemantic proximity Read ↗

Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development.Semantic proximity Read ↗

Embryonic Tbx3+ cardiomyocytes form the mature cardiac conduction system by progressive fate restrictionSemantic proximity Read ↗

Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic programSemantic proximity Read ↗

Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial diseaseSemantic proximity Read ↗

Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.Semantic proximity Read ↗

NOX2 Is Critical to Endocardial to Mesenchymal Transition and Heart DevelopmentSemantic proximity Read ↗

Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.Semantic proximity Read ↗

Tbx5 is essential for heart development.Semantic proximity Read ↗

Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formationSemantic proximity Read ↗

Coordinated <i>Tbx3/Tbx5</i> transcriptional control of the adult ventricular conduction systemSemantic proximity Read ↗

A novel TBX5 mutation predisposes to familial cardiac septal defects and atrial fibrillation as well as bicuspid aortic valveSemantic proximity Read ↗

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