Article
Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals.
Cell metabolism - 7 Mar 2017
Mauro Claudio, Smith Joanne, Cucchi Danilo, Coe David, Fu Hongmei, Bonacina Fabrizia, Baragetti Andrea, Cermenati Gaia, Caruso Donatella, Mitro Nico, Catapano Alberico L, Ammirati Enrico, Longhi Maria P, Okkenhaug Klaus, Norata Giuseppe D, Marelli-Berg Federica M
Abstract excerpt
Low-grade systemic inflammation associated to obesity leads to cardiovascular complications, caused partly by infiltration of adipose and vascular tissue by effector T cells. The signals leading to T cell differentiation and tissue infiltration during obesity are poorly understood. We tested whether saturated fatty acid-induced metabolic stress affects differentiation and trafficking patterns of CD4+ T cells....
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