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Article

Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity.

Scientific reports - 10 Jul 2020

Gans Ian, Hartig Ellen I, Zhu Shusen, Tilden Andrea R, Hutchins Lucie N, Maki Nathaniel J, Graber Joel H, Coffman James A

Abstract excerpt

The zebrafish has recently emerged as a model system for investigating the developmental roles of glucocorticoid signaling and the mechanisms underlying glucocorticoid-induced developmental programming. To assess the role of the Glucocorticoid Receptor (GR) in such programming, we used CRISPR-Cas9 to produce a new frameshift mutation, GR369-, which eliminates all potential in-frame initiation codons upstream of...

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Identifiers

PMID: 32651405
DOI: 10.1038/s41598-020-68040-z
PMCID: PMC7351738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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