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Article

Glucocorticoid receptor signaling is essential for mesoderm formation and muscle development in zebrafish.

Endocrinology - 1 Mar 2012

Nesan Dinushan, Kamkar Maryam, Burrows Jeffrey, Scott Ian C, Marsden Mungo, Vijayan Mathilakath M

Abstract excerpt

Glucocorticoid receptor (GR) signaling is thought to play a key role in embryogenesis, but its specific developmental effects remain unclear. Cortisol is the primary ligand for GR activation in teleosts, and in zebrafish (Danio rerio), the prehatch embryo content of this steroid is of maternal origin. Using early zebrafish developmental stages, we tested the hypothesis that GR signaling is critical for embryo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22234471
DOI: 10.1210/en.2011-1559

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