Optogenetic induction of chronic glucocorticoid exposure in early-life impairs stress-response in larval zebrafish

Abstract excerpt

Organisms respond to stressors through a coordinated set of physiological and behavioural responses. Zebrafish provides an opportunity to study conserved mechanisms underlying the stress-response that is regulated largely by the neuroendocrine Hypothalamus-Pituitary-Adrenal/Interrenal (HPA) axis, with glucocorticoids (GC) as the final effector. In this study, we evaluated the effect of chronically active GC signal...

Topics

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• Congenital heart defects research
• CRISPR-Cas Systems
• Frameshift Mutation
• Hydrocortisone
• Kruppel-Like Transcription Factors
• Receptors, Glucocorticoid
• Receptors, Mineralocorticoid
• Zebrafish Biomedical Research Applications

Identifiers and source

Literature Corpus work

c367c789-a154-5a04-9f86-0b144548d30a

DOI

10.1101/2022.09.09.507267