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Article

Cortisol-treated zebrafish embryos develop into pro-inflammatory adults with aberrant immune gene regulation

21 Jul 2016

Abstract excerpt

Chronic early-life stress increases adult susceptibility to numerous health problems linked to chronic inflammation. One way that this may occur is via glucocorticoid-induced developmental programming. To gain insight into such programming we treated zebrafish embryos with cortisol and examined the effects on both larvae and adults. Treated larvae had elevated whole-body cortisol and glucocorticoid signaling, and...

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PMID: 27444789
DOI: 10.1242/bio.020065

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