Genome sequencing unveils a regulatory landscape of platelet reactivity.

doi:10.1038/s41467-021-23470-9

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Article

Genome sequencing unveils a regulatory landscape of platelet reactivity.

Nature communications - 15 Jun 2021

Keramati Ali R, Chen Ming-Huei, Rodriguez Benjamin A T, Yanek Lisa R, Bhan Arunoday, Gaynor Brady J, Ryan Kathleen, Brody Jennifer A, Zhong Xue, Wei Qiang, Kammers Kai, Kanchan Kanika, Iyer Kruthika, Kowalski Madeline H, Pitsillides Achilleas N, Cupples L Adrienne, Li Bingshan, Schlaeger Thorsten M, Shuldiner Alan R, O'Connell Jeffrey R, Ruczinski Ingo, Mitchell Braxton D, Faraday Nauder, Taub Margaret A, Becker Lewis C, Lewis Joshua P, Mathias Rasika A, Johnson Andrew D

Abstract excerpt

Platelet aggregation at the site of atherosclerotic vascular injury is the underlying pathophysiology of myocardial infarction and stroke. To build upon prior GWAS, here we report on 16 loci identified through a whole genome sequencing (WGS) approach in 3,855 NHLBI Trans-Omics for Precision Medicine (TOPMed) participants deeply phenotyped for platelet aggregation. We identify the RGS18 locus, which encodes a...

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PMID: 34131117
DOI: 10.1038/s41467-021-23470-9
PMCID: PMC8206369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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