Article
A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters.
Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2006
Saxonov Serge, Berg Paul, Brutlag Douglas L
Abstract excerpt
A striking feature of the human genome is the dearth of CpG dinucleotides (CpGs) interrupted occasionally by CpG islands (CGIs), regions with relatively high content of the dinucleotide. CGIs are generally associated with promoters; genes, whose promoters are especially rich in CpG sequences, tend to be expressed in most tissues. However, all working definitions of what constitutes a CGI rely on ad hoc...
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