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Article

Next-generation sequencing demonstrates the rarity of short kinase variants specific to quadruple wild-type gastrointestinal stromal tumours.

Journal of clinical pathology - 1 Mar 2021

Wong Newton A C S, Giger Olivier T, Ten Hoopen Rogier, Casey Ruth T, Russell Kirsty, Faulkner Claire

Abstract excerpt

AIM: There is no known specific biomarker or genetic signal for quadruple wild-type (qWT) gastrointestinal stromal tumours (GISTs). By next-generation sequencing (NGS) of different GIST subgroups, this study aimed to characterise such a biomarker especially as a potential therapeutic target. METHODS AND RESULTS: An NGS panel of 672 kinase genes was applied to DNA extracted from 11 wild-type GISTs (including three...

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Identifiers

PMID: 32646927
DOI: 10.1136/jclinpath-2020-206613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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