Article
Gastrointestinal stromal tumours: origin and molecular oncology.
Nature reviews. Cancer - 17 Nov 2011
Corless Christopher L, Barnett Christine M, Heinrich Michael C
Abstract excerpt
Gastrointestinal stromal tumours (GISTs) are a paradigm for the development of personalized treatment for cancer patients. The nearly simultaneous discovery of a biomarker that is reflective of their origin and the presence of gain-of-function kinase mutations in these tumours set the stage for more accurate diagnosis and the development of kinase inhibitor therapy. Subsequent studies of genotype and phenotype...
Topics
Join the communities discussing this publication.