Article
Frequent KIT mutations in human gastrointestinal stromal tumors.
Scientific reports - 1 Aug 2014
Xu Zhi, Huo Xinying, Tang Chuanning, Ye Hua, Nandakumar Vijayalakshmi, Lou Feng, Zhang Dandan, Jiang Shouwen, Sun Hong, Dong Haichao, Zhang Guangchun, Liu Zhiyuan, Dong Zhishou, Guo Baishuai, Yan He, Yan Chaowei, Wang Lu, Su Ziyi, Li Yangyang, Gu Dongying, Zhang Xiaojing, Wu Xiaomin, Wei Xiaowei, Hong Lingzhi, Zhang Yangmei, Yang Jinsong, Gong Yonglin, Tang Cuiju, Jones Lindsey, Huang Xue F, Chen Si-Yi, Chen Jinfei
Abstract excerpt
Identifying gene mutations in individual tumors is critical to improve the efficacy of cancer therapy by matching targeted drugs to specific mutations. Gastrointestinal stromal tumors (GIST) are stromal or mesenchymal subepithelial neoplasms affecting the gastrointestinal tract and frequently contain activating gene mutations in either KIT or platelet-derived growth factor A (PDGFRA). Although GIST is highly...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.