Article
Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression.
Cancer research - 15 Sept 2020
Midorikawa Yutaka, Yamamoto Shogo, Tatsuno Kenji, Renard-Guillet Claire, Tsuji Shingo, Hayashi Akimasa, Ueda Hiroki, Fukuda Shiro, Fujita Takanori, Katoh Hiroto, Ishikawa Shumpei, Covington Kyle R, Creighton Chad J, Sugitani Masahiko, Wheeler David A, Shibata Tatsuhiro, Nagae Genta, Takayama Tadatoshi, Aburatani Hiroyuki
Abstract excerpt
Cancer develops through the accumulation of genetic and epigenetic aberrations. To identify sequential molecular alterations that occur during the development of hepatocellular carcinoma (HCC), we compared 52 early and 108 overt HCC samples by genome sequencing. Gene mutations in the p53/RB1 pathway, WNT pathway, MLL protein family, SWI/SNF complexes, and AKT/PI3K pathway were common in HCC. In the early phase of...
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