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Article

Prognostic Significance of RAS Mutations and P53 Expression in Cutaneous Squamous Cell Carcinomas.

Genes - 6 Jul 2020

Campos Manuel António, Macedo Sofia, Fernandes Margarida Sá, Pestana Ana, Pardal Joana, Batista Rui, Vinagre João, Sanches Agostinho, Baptista Armando, Lopes José Manuel, Soares Paula

Abstract excerpt

TP53 is considered the most commonly-altered gene in cutaneous squamous cell carcinoma (cSCC). Conversely, RAS mutations have been reported in a low percentage of cSCC. The objective of our study was to evaluate the frequency of p53 expression and RAS mutations in cSCC and correlate them with clinicopathological features and patient outcome. We performed immunohistochemistry for p53 and genetic profiling for RAS...

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Identifiers

PMID: 32640663
DOI: 10.3390/genes11070751
PMCID: PMC7397334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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