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Article

CDKN2A but not TP53 mutations nor HPV presence predict poor outcome in metastatic squamous cell carcinoma of the skin.

International journal of cancer - 1 May 2010

Küsters-Vandevelde Heidi V N, Van Leeuwen Arjanne, Verdijk Marian A J, de Koning Maurits N C, Quint Wim G V, Melchers Willem J G, Ligtenberg Marjolijn J L, Blokx Willeke A M

Abstract excerpt

Genetic alterations in metastatic cutaneous squamous cell carcinoma (CSCC) which might serve as prognostic biomarkers are not well investigated. We investigated the mutation status and protein expression of the CDKN2A (INK4a-ARF) and TP53 genes in metastatic CSCCs and correlated this with clinicopathological variables, HPV presence, and survival data. Sequence analysis was performed on formalin-fixed and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19739123
DOI: 10.1002/ijc.24871

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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