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Article

Major p53 immunohistochemical patterns in in situ and invasive squamous cell carcinomas of the vulva and correlation with TP53 mutation status.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2020

Tessier-Cloutier Basile, Kortekaas Kim E, Thompson Emily, Pors Jennifer, Chen Julia, Ho Julie, Prentice Leah M, McConechy Melissa K, Chow Christine, Proctor Lily, McAlpine Jessica N, Huntsman David G, Gilks C Blake, Bosse Tjalling, Hoang Lynn N

Abstract excerpt

The recent literature has shown that vulvar squamous cell carcinoma (VSCC) can be stratified into two prognostically relevant groups based on human papillomavirus (HPV) status. The prognostic value of p53 for further sub-stratification, particularly in the HPV-independent group, has not been agreed upon. This disagreement is likely due to tremendous variations in p53 immunohistochemical (IHC) interpretation. To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32203095
DOI: 10.1038/s41379-020-0524-1

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