Genetic basis of induction and overproduction of chromosomal class I beta-lactamase in nonfastidious gram-negative bacilli.

Abstract excerpt

Pseudomonas and several species of gram-negative enterobacteria produce low levels of chromosomally encoded class I beta-lactamase. The level of synthesis can be greatly increased by the addition of beta-lactam antibiotics into the growth medium. Moreover, mutants overproducing the enzyme arise at a high frequency in these species. The beta-lactamase is encoded by the chromosomal ampC gene, and its induction is...

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