Article
Molecular mechanisms of beta-lactam resistance mediated by AmpC hyperproduction in Pseudomonas aeruginosa clinical strains.
Antimicrobial agents and chemotherapy - 1 Nov 2005
Juan Carlos, Maciá María D, Gutiérrez Olivia, Vidal Carmen, Pérez José L, Oliver Antonio
Abstract excerpt
The molecular mechanisms of beta-lactam resistance mediated by AmpC hyperproduction in natural strains of Pseudomonas aeruginosa were investigated in a collection of 10 isogenic, ceftazidime-susceptible and -resistant pairs of isolates, each sequentially recovered from a different intensive care unit patient treated with beta-lactams. All 10 ceftazidime-resistant mutants hyper-produced AmpC (beta-lactamase...
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