Article
AmpD is required for regulation of expression of NmcA, a carbapenem-hydrolyzing beta-lactamase of Enterobacter cloacae.
Antimicrobial agents and chemotherapy - 1 Oct 2001
Naas T, Massuard S, Garnier F, Nordmann P
Abstract excerpt
To further elucidate the induction process of the carbapenem-hydrolyzing beta-lactamase of Ambler class A, NmcA, ampD genes of the wild-type (WT) strain and of ceftazidime-resistant mutants of Enterobacter cloacae NOR-1 were cloned and tested in transcomplementation experiments. Ceftazidime-resistant E. cloacae NOR-1 mutants exhibited derepressed expression of the AmpC-type cephalosporinase and of the...
Topics
- Alleles
- Amino Acid Sequence
- Bacterial Proteins
- Carbapenems
- Drug Resistance, Bacterial
- Enterobacter cloacae
- Gene Expression Regulation
- Genetic Complementation Test
- Molecular Sequence Data
- N-Acetylmuramoyl-L-alanine Amidase
- Sequence Homology, Amino Acid
- beta-Lactamases