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Article

Deacetylation by SIRT1 promotes the tumor-suppressive activity of HINT1 by enhancing its binding capacity for β-catenin or MITF in colon cancer and melanoma cells.

Experimental & molecular medicine - 1 Jul 2020

Jung Taek-Yeol, Jin Gyu-Rin, Koo Young-Bin, Jang Mi-Mi, Kim Chan-Woo, Lee Soh-Yeon, Kim Hyelee, Lee Chae-Young, Lee Soo-Young, Ju Bong-Gun, Kim Hyun-Seok

Abstract excerpt

Histidine triad nucleotide-binding protein 1 (HINT1), which belongs to the evolutionarily conserved HIT superfamily, has been shown to possess a tumor-suppressive function by binding to and inhibiting several oncogenic transcription factors, such as β-catenin and microphthalmia transcription factor (MITF), in various types of cancer cells. However, the regulatory mechanism that mediates the binding capacity of...

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Identifiers

PMID: 32636443
DOI: 10.1038/s12276-020-0465-2
PMCID: PMC8080686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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