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Article

Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis.

Nature communications - 7 Jul 2020

Tan Yong Zi, Rodrigues José, Keener James E, Zheng Ruixiang Blake, Brunton Richard, Kloss Brian, Giacometti Sabrina I, Rosário Ana L, Zhang Lei, Niederweis Michael, Clarke Oliver B, Lowary Todd L, Marty Michael T, Archer Margarida, Potter Clinton S, Carragher Bridget, Mancia Filippo

Abstract excerpt

Arabinosyltransferase B (EmbB) belongs to a family of membrane-bound glycosyltransferases that build the lipidated polysaccharides of the mycobacterial cell envelope, and are targets of anti-tuberculosis drug ethambutol. We present the 3.3 Å resolution single-particle cryo-electron microscopy structure of Mycobacterium smegmatis EmbB, providing insights on substrate binding and reaction mechanism. Mutations that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32636380
DOI: 10.1038/s41467-020-17202-8
PMCID: PMC7341804

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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