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Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolution

18 Sept 2018

Abstract excerpt

Tuberculosis (TB) is a devastating and rapidly spreading disease caused by Mycobacterium tuberculosis (Mtb). Therapy requires prolonged treatment with a combination of multiple agents and interruptions in the treatment regimen result in emergence and spread of multi-drug resistant (MDR) Mtb strains. MDR Mtb poses a significant global health problem, calling for urgent development of novel drugs to combat TB....

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PMID: 30250274
DOI: 10.1038/s41467-018-06440-6

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