Article
Mycobacterial ethambutol responsive genes and implications in antibiotics resistance.
Journal of drug targeting - 1 Mar 2021
Xiang Xiaohong, Gong Zhen, Deng Wanyan, Sun Qingyu, Xie Jianping
Abstract excerpt
Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis (TB), remains a formidable threat in mortality and morbidity worldwide. Ethambutol (EMB) is one of the first-line drugs regimens for TB treatment. Arabinosyl transferases are established targets of EMB, which is involved in the biosynthesis of arabinogalactan (AG) and lipoarabinomannan (LAM). Mutations among embCAB operon are...
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