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Article

Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2

3 May 2020

Abstract excerpt

Inhibition of Mycobacterium tuberculosis (Mtb) cell wall assembly is an established strategy for anti-TB chemotherapy. Arabinosyltransferase EmbB, which catalyzes the transfer of arabinose from the donor decaprenyl-phosphate-arabinose (DPA) to its arabinosyl acceptor is an essential enzyme for Mtb cell wall synthesis. Analysis of drug resistance mutations suggests that EmbB is the main target of the front-line...

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PMID: 32363534
DOI: 10.1007/s13238-020-00726-6

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