Article
Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria.
Molecular cell - 21 May 2020
Tan Yong Zi, Zhang Lei, Rodrigues José, Zheng Ruixiang Blake, Giacometti Sabrina I, Rosário Ana L, Kloss Brian, Dandey Venkata P, Wei Hui, Brunton Richard, Raczkowski Ashleigh M, Athayde Diogo, Catalão Maria João, Pimentel Madalena, Clarke Oliver B, Lowary Todd L, Archer Margarida, Niederweis Michael, Potter Clinton S, Carragher Bridget, Mancia Filippo
Abstract excerpt
Mycobacterium tuberculosis causes tuberculosis, a disease that kills over 1 million people each year. Its cell envelope is a common antibiotic target and has a unique structure due, in part, to two lipidated polysaccharides-arabinogalactan and lipoarabinomannan. Arabinofuranosyltransferase D (AftD) is an essential enzyme involved in assembling these glycolipids. We present the 2.9-Å resolution structure of...
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