Article
Genetic associations with valvular calcification and aortic stenosis.
The New England journal of medicine - 7 Feb 2013
Thanassoulis George, Campbell Catherine Y, Owens David S, Smith J Gustav, Smith Albert V, Peloso Gina M, Kerr Kathleen F, Pechlivanis Sonali, Budoff Matthew J, Harris Tamara B, Malhotra Rajeev, O'Brien Kevin D, Kamstrup Pia R, Nordestgaard Børge G, Tybjaerg-Hansen Anne, Allison Matthew A, Aspelund Thor, Criqui Michael H, Heckbert Susan R, Hwang Shih-Jen, Liu Yongmei, Sjogren Marketa, van der Pals Jesper, Kälsch Hagen, Mühleisen Thomas W, Nöthen Markus M, Cupples L Adrienne, Caslake Muriel, Di Angelantonio Emanuele, Danesh John, Rotter Jerome I, Sigurdsson Sigurdur, Wong Quenna, Erbel Raimund, Kathiresan Sekar, Melander Olle, Gudnason Vilmundur, O'Donnell Christopher J, Post Wendy S
Abstract excerpt
BACKGROUND: Limited information is available regarding genetic contributions to valvular calcification, which is an important precursor of clinical valve disease. METHODS: We determined genomewide associations with the presence of aortic-valve calcification (among 6942 participants) and mitral annular calcification (among 3795 participants), as detected by computed tomographic (CT) scanning; the study population...
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