Article
Calcific Aortic Valve Stenosis and Atherosclerotic Calcification.
Current atherosclerosis reports - 7 Jan 2020
de Oliveira Sá Michel Pompeu Barros, Cavalcanti Luiz Rafael P, Perazzo Álvaro M, Gomes Rafael A F, Clavel Marie-Annick, Pibarot Philippe, Biondi-Zoccai Giuseppe, Zhigalov Konstantin, Weymann Alexander, Ruhparwar Arjang, Lima Ricardo Carvalho
Abstract excerpt
PURPOSE OF REVIEW: This review summarizes the pathophysiology of calcific aortic valve stenosis (CAVS) and surveys relevant clinical data and basic research that explain how CAVS arises. RECENT FINDINGS: Lipoprotein(a) [Lp(a)], lipoprotein-associated phospholipase A2 (Lp-PLA2), oxidized phospholipids (OxPL), autotaxin, and genetic driving forces such as mutations in LPA gene and NOTCH gene seem to play a major...
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