Article
Exploring neighborhoods in large metagenome assembly graphs using spacegraphcats reveals hidden sequence diversity.
Genome biology - 6 Jul 2020
Brown C Titus, Moritz Dominik, O'Brien Michael P, Reidl Felix, Reiter Taylor, Sullivan Blair D
Abstract excerpt
Genomes computationally inferred from large metagenomic data sets are often incomplete and may be missing functionally important content and strain variation. We introduce an information retrieval system for large metagenomic data sets that exploits the sparsity of DNA assembly graphs to efficiently extract subgraphs surrounding an inferred genome. We apply this system to recover missing content from genome bins...
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