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Article

A survey of sequence-to-graph mapping algorithms in the pangenome era.

Genome biology - 22 May 2025

Cui Yingbo, Peng Chenchen, Xia Zeyu, Yang Canqun, Guo Yifei

Abstract excerpt

A pangenome can reveal the genetic diversity across different individuals simultaneously. It offers a more comprehensive reference for genome analysis compared to a single linear genome that may introduce allele bias. Pangenomes are often represented as genome graphs, making sequence-to-graph mapping a fundamental task for pangenome construction and analysis. Numerous sequence-to-graph mapping algorithms have...

Read the complete abstract on PubMed

Topics

Algorithms
Humans
Genomics
Chromosome Mapping
Genetic Variation
Sequence Analysis, DNA
Genome

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Identifiers

PMID: 40405275
DOI: 10.1186/s13059-025-03606-6
PMCID: PMC12096488

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