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Article

Comparative analysis of somatic variant calling on matched FF and FFPE WGS samples.

BMC medical genomics - 6 Jul 2020

de Schaetzen van Brienen Louise, Larmuseau Maarten, Van der Eecken Kim, De Ryck Frederic, Robbe Pauline, Schuh Anna, Fostier Jan, Ost Piet, Marchal Kathleen

Abstract excerpt

BACKGROUND: Research grade Fresh Frozen (FF) DNA material is not yet routinely collected in clinical practice. Many hospitals, however, collect and store Formalin Fixed Paraffin Embedded (FFPE) tumor samples. Consequently, the sample size of whole genome cancer cohort studies could be increased tremendously by including FFPE samples, although the presence of artefacts might obfuscate the variant calling. To...

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Identifiers

PMID: 32631411
DOI: 10.1186/s12920-020-00746-5
PMCID: PMC7336445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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