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Article

Retrovirus reactivation in CHMP2BIntron5 models of frontotemporal dementia.

Human molecular genetics - 29 Sept 2020

Fort-Aznar Laura, Ugbode Chris, Sweeney Sean T

Abstract excerpt

Frontotemporal dementia (FTD) is the second most prevalent form of pre-senile dementia after Alzheimer's disease. Amyotrophic lateral sclerosis (ALS) can overlap genetically, pathologically and clinically with FTD indicating the two conditions are ends of a spectrum and may share common pathological mechanisms. FTD-ALS causing mutations are known to be involved in endosomal trafficking and RNA regulation. Using...

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Identifiers

PMID: 32628265
DOI: 10.1093/hmg/ddaa142
PMCID: PMC7530534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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