Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reversal of pathology in CHMP2B-mediated frontotemporal dementia patient cells using RNA interference.

The journal of gene medicine - 1 Aug 2012

Nielsen Troels Tolstrup, Mizielinska Sarah, Hasholt Lis, Isaacs Adrian M, Nielsen Jørgen E

Abstract excerpt

BACKGROUND: Frontotemporal dementia is the second most common form of young-onset dementia after Alzheimer's disease, and several genetic forms of frontotemporal dementia are known. A rare genetic variant is caused by a point mutation in the CHMP2B gene. CHMP2B is a component of the ESCRT-III complex, which is involved in endosomal trafficking of proteins targeted for degradation in lysosomes. Mutations in CHMP2B...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endosomal Sorting Complexes Required for Transport
Share to Endosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Frontotemporal Dementia

Share to Gene Knockdown Techniques

Share to Genetic Therapy

Share to Genetic Vectors

Share to Lentivirus

Share to RNA, Small Interfering

Source

Identifiers

PMID: 22786763
DOI: 10.1002/jgm.2649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reversal of pathology in CHMP2B-mediated frontotemporal dementia patient cells using RNA interference.PMID 22786763Read ↗

The role of CHMP2B in frontotemporal dementiaSemantic proximity Read ↗

Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue byTMEM106BknockdownSemantic proximity Read ↗

Disruption of endocytic trafficking in frontotemporal dementia with CHMP2B mutations.Semantic proximity Read ↗

Frontotemporal dementia caused by CHMP2B mutations.Semantic proximity Read ↗

Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic miceSemantic proximity Read ↗

Lessons learned from CHMP2B, implications for frontotemporal dementia and amyotrophic lateral sclerosis.Semantic proximity Read ↗

Truncation mutation of CHMP2B disrupts late endosome function but reduces TDP-43 aggregation through HSP70 upregulation.Semantic proximity Read ↗

The role of CHMP2BIntron5 in autophagy and frontotemporal dementia.Semantic proximity Read ↗

Mislocalization of FTD3-associated mutant CHMP2B to the nucleus of human neurons due to loss of a nuclear export signal.Semantic proximity Read ↗

A novel splice-site mutation in CHMP2B associated with frontotemporal dementia: The first report from China and literature review.Semantic proximity Read ↗

Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia.Semantic proximity Read ↗

CHMP2B mutants linked to frontotemporal dementia impair maturation of dendritic spines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.