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Article

FCGR3A F158V alleles frequency differs in multiple myeloma patients from healthy population.

Oncoimmunology - 1 Jan 2024

Constantinides Michaël, Robert Nicolas, Multrier Caroline, Coënon Loïs, Campos-Mora Mauricio, Jacquard Carine, Gao Fei, Zemiti Sara, Presumey Jessy, Cartron Guillaume, Moreaux Jérome, Villalba Martin

Abstract excerpt

FCGR3A presents a single nucleotide polymorphism at location 158 (V/F), which affects its binding to the fragment crystallizable (Fc) of antibodies (Abs). FcγRIIIa-158 V allotype has the highest affinity and is associated with a better clinical response to IgG1 monoclonal Abs (mAb) treatment. We compared the allele frequency of FCGR3A-F158V polymorphism in cohorts of patients with B-cell lymphoproliferative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39175948
DOI: 10.1080/2162402X.2024.2388306
PMCID: PMC11340758

Genes

FCGR3A
CD38
CD4

Variants

Provenance

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