Article

The arming of NK cells with Fc-engineered rituximab confers them specificity against CD20-expressing cells

2024-03-11

Abstract excerpt

<title>Abstract</title> <p>Clinical effects of IgG1 monoclonal antibodies (mAb) relies on various mechanisms, including antibody dependent cell-mediated cytotoxicity (ADCC), which requires natural killer (NK) cells as the main immune effectors. These cells are emerging as significant tools for cancer cell therapies, presenting a potential alternative to Chimeric Antigen Receptor-T (CAR-T) cell therapies. We gener...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5447c8c2-8c15-5015-a889-bb04493b4e0e
DOI: 10.21203/rs.3.rs-4017845/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The arming of NK cells with Fc-engineered rituximab confers them specificity against CD20-expressing cellsDOI 10.21203/rs.3.rs-4017845/v1Read

Reimagining antibody-dependent cellular cytotoxicity in cancer: the potential of natural killer cell engagersSemantic proximity Read

A CHIMERIC RECEPTOR ENABLING ANTIBODY-GUIDED RETARGETING OF CAR T- CELLSSemantic proximity Read

Construction and characterization of chimeric FcγR T cells for universal T cell therapySemantic proximity Read

FcεRIγ-negative NK cells persist in vivo and enhance efficacy of therapeutic monoclonal antibodies in multiple myelomaSemantic proximity Read

A Novel Feeder cell based on 4-1BBL and Membrane-bound IL-21/ IL-15 Induce Highly Expansion and Anti-tumor Effect of Natural Killer CellsSemantic proximity Read

A Novel Natural Killer Cell Expansion Technology for the Development of Cellular ImmunotherapiesSemantic proximity Read

Rituximab induces phenotypical and functional changes of NK cells in a non-malignant experimental setting.Semantic proximity Read

Nanobody Armed T Cells Endow CAR-T Cells the Ability to Against Lymphoma CellsSemantic proximity Read

Cell therapy could benefit from BCG: how anti-tumour BCG-primed NK cells selectively proliferate over other lymphocytes and efficiently kill cancer cellsSemantic proximity Read

CD20‐Specific Immunoligands Engaging NKG2D Enhance γδ T Cell‐Mediated Lysis of Lymphoma CellsSemantic proximity Read

Anti-CD20 rituximab IgG1, IgG3, and IgG4 but not IgG2 subclass trigger Ca2+ mobilization and cytotoxicity in human NK cells.Semantic proximity Read

<i>Bona fide</i> cytotoxic iNKT cells with superior antitumour responses identified in mice and humansSemantic proximity Read