Article
NK Cell and Ig Interplay in Defense against Herpes Simplex Virus Type 1: Epistatic Interaction of CD16A and IgG1 Allotypes of Variable Affinities Modulates Antibody-Dependent Cellular Cytotoxicity and Susceptibility to Clinical Reactivation.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2015
Moraru Manuela, Black Laurel E, Muntasell Aura, Portero Francisca, López-Botet Miguel, Reyburn Hugh T, Pandey Janardan P, Vilches Carlos
Abstract excerpt
HSV-1 latently infects most humans, causing a variable clinical picture that depends, in part, on host genetic factors. Both IgG and its cellular FcRs, CD16A and CD32A-C (encoded by FCGR3A and FCGR2A-C, respectively, on chromosome 1), display polymorphisms that could affect their defensive function. Of potential relevance are a FCGR3A dimorphism resulting in CD16A-valine/phenylalanine-158 allotypes with different...
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