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pTDP-43 levels correlate with cell type specific molecular alterations in the prefrontal cortex of <i>C9orf72</i> ALS/FTD patients

2023-01-13

Abstract excerpt

Repeat expansions in the C9orf72 gene are the most common genetic cause of amyotrophic lateral sclerosis and familial frontotemporal dementia (ALS/FTD). To identify molecular defects that take place in the dorsolateral frontal cortex of patients with C9orf72 ALS/FTD, we compared healthy controls with C9orf72 ALS/FTD donor samples staged based on the levels of cortical phosphorylated TAR DNA binding protein (pTD...

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Literature Corpus work
c294ef56-f3fd-505b-945c-074623fb3a0a
DOI
10.1101/2023.01.12.523820
Open publication

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pTDP-43 levels correlate with cell type specific molecular alterations in the prefrontal cortex of <i>C9orf72</i> ALS/FTD patientsDOI 10.1101/2023.01.12.523820
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