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DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169

17 Feb 2019

Abstract excerpt

Human Dual-specificity tyrosine (Y) Regulated Kinase 1A (DYRK1A) is encoded by a dosage dependent gene whereby either trisomy or haploinsufficiency result in developmental abnormalities. However, the function and regulation of this important protein kinase are not fully understood. Here, we report proteomic analysis of DYRK1A in human cells that revealed a novel role of DYRK1A in DNA double-strand breaks (DSBs)...

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PMID: 30773093
DOI: 10.1080/15384101.2019.1577525

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DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169PMID 30773093Read ↗

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