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The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair

25 Apr 2019

Abstract excerpt

The chromosome 21 encoded protein kinase DYRK1A is essential for normal human development. Mutations in DYRK1A underlie a spectrum of human developmental disorders, and increased dosage in trisomy 21 is implicated in Down syndrome related pathologies. DYRK1A regulates a diverse array of cellular processes through physical interactions with substrates and binding partners in various subcellular compartments....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 31024071
DOI: 10.1038/s41598-019-42990-5

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The nuclear interactome of DYRK1A reveals a functional role in DNA damage repairPMID 31024071Read ↗

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DYRK1A interacts with histone acetyl transferase p300 and CBP and localizes to enhancersSemantic proximity Read ↗

Defining novel targets and functions of the protein kinase DYRK2Semantic proximity Read ↗

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