The Association of MUC16 Mutation with Tumor Mutation Burden and Its Prognostic Implications in Cutaneous Melanoma.

doi:10.1158/1055-9965.EPI-20-0307

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Article

The Association of MUC16 Mutation with Tumor Mutation Burden and Its Prognostic Implications in Cutaneous Melanoma.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2020

Wang Xuefeng, Yu Xiaoqing, Krauthammer Michael, Hugo Willy, Duan Chunzhe, Kanetsky Peter A, Teer Jamie K, Thompson Zachary J, Kalos Denise, Tsai Kenneth Y, Smalley Keiran S M, Sondak Vernon K, Chen Y Ann, Conejo-Garcia Jose R

Abstract excerpt

BACKGROUND: MUC16 is a mucin marker that is frequently mutated in melanoma, but whether MUC16 mutations could be useful as a surrogate biomarker for tumor mutation burden (TMB) remains unclear. METHODS: This study rigorously evaluates the MUC16 mutation as a clinical biomarker in cutaneous melanoma by utilizing genomic and clinical data from patient samples from The Cancer Genome Atlas (TCGA) and two independent...

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Identifiers

PMID: 32611582
DOI: 10.1158/1055-9965.EPI-20-0307
PMCID: PMC7483810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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