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Gender and melanoma subtype-based prognostic implications of MUC16 and TTN co-occurrent mutations in melanoma: A retrospective multi-study analysis.

Cancer medicine - 1 Sept 2024

Kodali Nilesh, Alomary Simona, Bhattaru Abhijit, Eldaboush Ahmed, Schwartz Robert A, Lipner Shari R

Abstract excerpt

BACKGROUND: Most primary cutaneous melanomas have pathogenesis driven by ultraviolet exposure and genetic mutations, whereas acral lentiginous melanoma (ALM) and metastatic melanoma are much less, if at all, linked with the former. Thus, we evaluated both ultraviolet related and non-ultraviolet related melanomas. Mutations in the MUC16 and TTN genes commonly occur concurrently in these melanoma patients, but...

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Identifiers

PMID: 39240165
DOI: 10.1002/cam4.70199
PMCID: PMC11378355

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