MUC4, MUC16, and TTN genes mutation correlated with prognosis, and predicted tumor mutation burden and immunotherapy efficacy in gastric cancer and pan‐cancer

Abstract excerpt

Dear Editor, Previous studies reported that MUC16 mutation was associated with better prognosis and higher tumor mutation burden (TMB) in gastric cancer, while TTN mutation was associated with better response to immune checkpoint blockage in solid tumors, but the potential mechanisms were still unclear.1, 2 Through the analysis in TCGA gastric adenocarcinoma cohort (N = 443) and FUSCC gastric cancer cohort (N =...

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