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Article

Glycogen synthase kinase-3β ablation limits pancreatitis-induced acinar-to-ductal metaplasia.

The Journal of pathology - 1 Sept 2017

Ding Li, Liou Geou-Yarh, Schmitt Daniel M, Storz Peter, Zhang Jin-San, Billadeau Daniel D

Abstract excerpt

Acinar-to-ductal metaplasia (ADM) is a reversible epithelial transdifferentiation process that occurs in the pancreas in response to acute inflammation. ADM can rapidly progress towards pre-malignant pancreatic intraepithelial neoplasia (PanIN) lesions in the presence of mutant KRas and ultimately pancreatic adenocarcinoma (PDAC). In the present work, we elucidate the role and related mechanism of glycogen...

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Source

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Identifiers

PMID: 28639695
DOI: 10.1002/path.4928
PMCID: PMC6042855

Genes

ADM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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