Article
Computational analysis identifies druggable mutations in human rBAT mediated Cystinuria.
Journal of biomolecular structure & dynamics - 1 Sept 2021
Pandey Bharati, Aarthy Murali, Sharma Mahima, Singh Sanjeev Kumar, Kumar Vinay
Abstract excerpt
Culex quinquefasciatus Cqm1 protein acts as the receptor for Lysinibacillus sphaericus mosquito-larvicidal binary (BinAB) toxin that is used worldwide for mosquito control. We found amino acid transporter protein, rBAT, as phylogenetically closest Cqm1 homolog in humans. The present study reveals large evolutionary distance between Cqm1 and rBAT, and rBAT ectodomain lacks the sequence motif which serves as...
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