Article

Identification and classification of ion-channels across the tree of life provide functional insights into understudied CALHM channels

2025-02-18

Abstract excerpt

The ion channel (IC) genes encoded in the human genome play fundamental roles in cellular functions and disease and are one of the largest classes of druggable proteins. However, limited knowledge of the diverse molecular and cellular functions carried out by ICs presents a major bottleneck in developing selective chemical probes for modulating their functions in disease states. The wealth of sequence data availab...

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Literature Corpus work: c684fe7c-8c68-573a-b09c-c3bad67d87e1
DOI: 10.1101/2025.02.10.637530

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