Mutational studies to understand the structure-function relationship in multidrug efflux transporters: applications for distinguishing mutants with high specificity.

Abstract excerpt

Multidrug transporters play key roles for drug resistance, mediating the transport of organic compounds and substrate recognition. The specificity of substrates and functions of multidrug transporters are affected with amino acid substitutions. Hence, it is important to understand the effect of mutations in multidrug resistance proteins on transport function and substrate specificity. In this work, we have...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amino Acids
• Share to Antiporters