Article

Integrated metabolome and transcriptome analyses provide insight into colon cancer development by the gut microbiota

2020-07-25

Abstract excerpt

Colon cancer onset and progression is strongly associated with the presence, absence, or differences in relative abundances of certain microbial taxa in the gastrointestinal tract. However, specific mechanisms affecting disease susceptibility related to complex commensal bacterial mixtures are poorly understood. We used a multi-omics approach to determine how differences in the complex gut microbiome (GM) influenc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0d7be9a3-3aba-5d47-bdb3-63c28ca9c3d4
DOI: 10.1101/2020.07.24.220269

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated metabolome and transcriptome analyses provide insight into colon cancer development by the gut microbiotaDOI 10.1101/2020.07.24.220269Read

Inflammation, Gut Microbiota, and Metabolomic Shifts in Colorectal Cancer: Insights from Human and Mouse ModelsSemantic proximity Read

Gut microbiome-metabolites axis: A friend or foe to colorectal cancer progressionSemantic proximity Read

Integrated microbiome and metabolomic profiling reveals alterations across the adenoma–colorectal cancer sequenceSemantic proximity Read

Mapping the colorectal cancer microbiome and metabolomeSemantic proximity Read

Distinct Signatures of Tumor-Associated Microbiota and Metabolome in Low-Grade vs. High-Grade Dysplastic Colon Polyps: Inference of Their Role in Tumor Initiation and ProgressionSemantic proximity Read

Integrated analysis of the faecal metagenome and serum metabolome reveals the role of gut microbiome-associated metabolites in the detection of colorectal cancer and adenomaSemantic proximity Read

Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkersSemantic proximity Read

Integrated metagenomic and metabolomic analysis reveals distinct gut-microbiome-derived phenotypes in early-onset colorectal cancer.Semantic proximity Read

Metabolomic analysis reveals key changes in amino acid metabolism in colorectal cancer patientsSemantic proximity Read

Microbiome and metabolic features of tissues and feces reveal diagnostic biomarkers for colorectal cancerSemantic proximity Read

Paired microbiome and metabolome analyses associate bile acid changes with colorectal cancer progressionSemantic proximity Read

The footprints of gut microbial-mammalian co-metabolism.Semantic proximity Read