Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Impact of the NOD2/CARD15 Variant (3020insC) and PSMA6 Polymorphism (-8C>G) on the Development and Outcome of Multiple Myeloma.

BioMed research international - 1 Jan 2020

Zmorzyński S, Popek-Marciniec S, Styk W, Wojcierowska-Litwin M, Korszeń-Pilecka I, Szudy-Szczyrek A, Chocholska S, Hus M, Filip A A

Abstract excerpt

INTRODUCTION: Multiple myeloma (MM) is a hematological malignancy characterized by genetic variety. The 3020insC variant of the NOD2/CARD15 gene results in the upregulation of proinflammatory cytokines. Chronic inflammation and abnormal function of the proteasome system may lead to MM development. The polymorphism (-8C>G) in the PSMA6 gene affects proteasome activity. The aim of our study was to analyze the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Antineoplastic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apoptosis

Share to Genetic Predisposition to Disease

Share to Genotype

Share to Multiple Myeloma

Share to Nod2 Signaling Adaptor Protein

Share to Proteasome Endopeptidase Complex

Source

Open in PubMed Open full text

Identifiers

PMID: 32596371
DOI: 10.1155/2020/7629456
PMCID: PMC7298267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Impact of the NOD2/CARD15 Variant (3020insC) and PSMA6 Polymorphism (-8C>G) on the Development and Outcome of Multiple Myeloma.PMID 32596371Read ↗

MicroRNA-15a/16-1 cluster located at chromosome 13q14 is down-regulated but displays different expression pattern and prognostic significance in multiple myeloma.Semantic proximity Read ↗

NOD2/CARD15 gene mutations in patients with gouty arthritis.Semantic proximity Read ↗

The TT Genotype of the KIAA1524 rs2278911 Polymorphism Is Associated with Poor Prognosis in Multiple Myeloma.Semantic proximity Read ↗

Bortezomib-induced peripheral neuropathy: A genome-wide association study on multiple myeloma patients.Semantic proximity Read ↗

ACE Insertion/Deletion Polymorphism (rs4646994) Is Associated With the Increased Risk of Multiple MyelomaSemantic proximity Read ↗

Copy number variations could predict the outcome of bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma.Semantic proximity Read ↗

Genetic Susceptibility to Bortezomib-Induced Peripheral Neuroropathy: Replication of the Reported Candidate Susceptibility Loci.Semantic proximity Read ↗

Impact of Genetic Polymorphisms on Bortezomib-Induced Peripheral Neuropathy in Multiple Myeloma: A Systematic Review and Bioinformatics Analysis.Semantic proximity Read ↗

The Genetic Polymorphisms of NLRP3 Inflammasome Associated with T Helper Cells in Patients with Multiple Myeloma.Semantic proximity Read ↗

Genetic factors underlying the risk of bortezomib induced peripheral neuropathy in multiple myeloma patients.Semantic proximity Read ↗

Genetic Risk Factors for Bortezomib-induced Neuropathic Pain in an Asian Population: A Genome-wide Association Study in South Korea.Semantic proximity Read ↗

Genetic variations in multiple myeloma II: association with effect of treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.