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Article

The TT Genotype of the KIAA1524 rs2278911 Polymorphism Is Associated with Poor Prognosis in Multiple Myeloma.

Cells - 28 Mar 2023

Szudy-Szczyrek Aneta, Mlak Radosław, Mazurek Marcin, Krajka Tomasz, Chocholska Sylwia, Bitkowska Paulina, Jutrzenka Marta, Szczyrek Michał, Homa-Mlak Iwona, Krajka Andrzej, Małecka-Massalska Teresa, Hus Marek

Abstract excerpt

BACKGROUND: The KIAA1524 gene encodes an oncoprotein, CIP2A, which inhibits the phosphorylation of the Akt kinase B, stabilizes the c-Myc protein, and, through that, promotes cancerogenesis. An increase in CIP2A expression has been observed in numerous solid tumors and hematologic malignancies, including multiple myeloma (MM). The aim of our study was to evaluate the clinical impact of the functional single...

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PMID: 37048102
DOI: 10.3390/cells12071029
PMCID: PMC10093279

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