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Article

Impact of ADCYAP1R1 genotype on longitudinal fear conditioning in children: interaction with trauma and sex.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Sept 2020

Jovanovic Tanja, Stenson Anaïs F, Thompson Nadia, Clifford Aimee, Compton Alisha, Minton Sean, van Rooij Sanne J F, Stevens Jennifer S, Lori Adriana, Nugent Nicole, Gillespie Charles F, Bradley Bekh, Ressler Kerry J

Abstract excerpt

Dysregulated fear conditioned responses have been associated with PTSD in adults, with increased fear-potentiated startle (FPS) serving as a potential intermediate phenotype for PTSD risk. This phenotype has also been associated with stress-related ADCYAP1R1 gene variants in adult women. However, FPS and genotype have not yet been examined during development. The aim of this study was to examine developmental...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32590837
DOI: 10.1038/s41386-020-0748-2
PMCID: PMC7421882

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